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In certain embodiments, a composition comprises aldesleukin in a pharmaceutical suitable aqueous vehicle, for parenteral administration to a patient in need of IL 2 immunotherapy, in which the aldesleukin has been prepared using the production method of the disclosure that ensures that the aldesleukin is stable in a pharmaceutical liquid composition for at least a year doxycycline hyclate side effect Perhaps most puzzling is the lack of a decrease in LTP in Shank3 G G mice, a surprising finding given that decreased hippocampal LTP has been identified in Shank3 mouse models lacking exons 4 9 Bozdagi et al

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